Seeing Hypoxia: High-resolution, in vivo oximetry
While methods exist for measuring blood oxygenation, they can be invasive, low temopral and/or spatial resolution, superficial or expensive. Because oxy- and deoxyhemoglobin absorb light differently at different wavelengths, photoacoustic imaging can be used to generate a high resolution parametric map of the oxygen saturation of blood completely non-invasively. This allows for the real-time monitoring of functional processes with the added advantage of haivng this oximetry data fused with high resolution anatomical images.
Oxy-Hemo mode can be used for:
- Hypoxia assessment within the tumor microenvironment
- Ischemia measurement in stroke and myocardial infarction
- Longitudinal assessment of angiogenesis
- Hemodynamic response to therapy
- Studies of placental oxygenation