November 2020: Cardiac protection by the leptin-brain melanocortin system in heart failure

This is a recording of a LIVE webinar presented by Alexander da Silva, PhD, Research Scientist IV at the University of Mississippi Medical Center in Jackson, MS

Topics discussed in this webinar:

  • Leptin acts on the central nervous system (CNS) to improve cardiac function and slow/halt progression of heart failure induced by myocardial infarction
  • Leptin’s CNS-mediated cardiac protection in heart failure requires activation of the brain melanocortin system, and more specifically of melanocortin-4 receptors (MC4R)
  • The beneficial cardiac effects of the leptin-MC4R axis is accompanied by increased cardiomyocyte mitochondrial biogenesis and efficiency, substrate oxidation, and cardiomyocyte contractility
  • Q&A Session

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