Biomarker / Molecular Imaging
Visualize deep within anatomy of small animals in 2D or 3D for biomarker research
Molecular Imaging to Visualize and Analyze Biomarkers Deep within the Body
Quantification of biomarkers with contrast agents for ultrasound and photoacoustic imaging modes.
Biomarker research contributes significantly to breakthroughs in the understanding of disease progression as well as the validation of therapeutic treatments. Using ultrasound and photoacoustic contrast agents with the Vevo systems, biomarkers can thus be visualized deep within the anatomy of the animal in 2D or 3D with resolutions down to 30 µm completely non-invasively.
Published molecular imaging applications using the Vevo systems include biomarker quantification, monitoring drug delivery, cell tracking, diagnostics such as detection of metastatic cells, development and characterization of novel theranosic contrast agents and others.
In the drug development space, the multi-modal nature of the Vevo systems make them ideal for assessing response to therapy including morphology, tumor volume, angiogenesis, vascularity, perfusion and hypoxia as well as for assessing cardiotoxicity.
Molecular imaging can be performed on the Vevo imaging system using two categories of contrast agents:
- Non-toxic, micron-sized agents which stay within the vasculature
- Sensitivity down to the capillary level
- Contrast agents can be targeted or untargeted
- Truly translational - used in the clinic
- Typically sub-100nm sized agents which can extravasate for tissue labeling
- Can be customized for a wide variety of targets and applications
- Can be multi-modal for PET, MR, Optical or other imaging compatability
Mouse Kidney Perfusion with Non-Targerted Microbubbles Imaged in Nonlinear Contrast Mode.
Tumor Perfusion with Non-Targerted Microbubbles, Imaged with Nonlinear Contrast and Displayed as MIP.
3D rendering of a photoacoustic image (overlaid onto B-Mode) of the mouse hind limb after Indocyanine Green (ICG) injection that migrated into the popliteal lymph node. Hind Limb vasculature can be seen in red and purple.
Displaying 1 - 5 of 254 results found
Top Paper
Morphological, functional, and molecular assessment of breast cancer bone metastases by experimental ultrasound techniques compared with magnetic resonance imaging and histological analysis
Henrik Heinen, Lisa Seyler, Vanessa Popp, Konstantin Hellwig, Aline Bozec, Michael Uder, Stephan Ellmann, Tobias Bäuerle
Bone
.2021
;Top Paper
Contrast-Enhanced Multispectral Photoacoustic Imaging for Irregular Hepatectomy Navigation: A Pilot Study
Yueming Zhang, Jing Lv, Pingguo Liu, Xingyang Zhao, Kang Chen, Qiaolin Li, Liming Nie, Chihua Fang
ACS Biomaterials Science & Engineering
.2020
;Top Paper
Clinically-applicable perfluorocarbon-loaded nanoparticles for in vivo photoacoustic,19f magnetic resonance and fluorescent imaging
Edyta Swider, Khalid Daoudi, Alexander H.J. Staal, Olga Koshkina, N. Koen van Riessen, Eric van Dinther, I. Jolanda M. de Vries, Chris L. de Korte, Mangala Srinivas
Nanotheranostics
.2020
;Top Paper
Tetrazine-Derived Near-Infrared Dye as a Facile Reagent for Developing Targeted Photoacoustic Imaging Agents
Samantha Slikboer, Zoya Naperstkow, Nancy Janzen, Amber Faraday, Yohannes Soenjaya, Johann Le Floc’h, Salma Al-Karmi, Rowan Swann, Kevin Wyszatko, Christine E. M. Demore, Stuart Foster, John F. Valliant
Molecular Pharmaceutics
.2020
;Top Paper
Noninvasive monitoring of liver metastasis development via combined multispectral photoacoustic imaging and fluorescence diffuse optical tomography
Jonathan Lavaud, Maxime Henry, Pascal Gayet, Arnold Fertin, Julien Vollaire, Yves Usson, Jean-Luc Coll, Véronique Josserand
International Journal of Biological Sciences
.2020
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