Biomarker / Molecular Imaging
Visualize deep within anatomy of small animals in 2D or 3D for biomarker research
Molecular Imaging to Visualize and Analyze Biomarkers Deep within the Body
Quantification of biomarkers with contrast agents for ultrasound and photoacoustic imaging modes.
Biomarker research contributes significantly to breakthroughs in the understanding of disease progression as well as the validation of therapeutic treatments. Using ultrasound and photoacoustic contrast agents with the Vevo systems, biomarkers can thus be visualized deep within the anatomy of the animal in 2D or 3D with resolutions down to 30 µm completely non-invasively.
Published molecular imaging applications using the Vevo systems include biomarker quantification, monitoring drug delivery, cell tracking, diagnostics such as detection of metastatic cells, development and characterization of novel theranosic contrast agents and others.
In the drug development space, the multi-modal nature of the Vevo systems make them ideal for assessing response to therapy including morphology, tumor volume, angiogenesis, vascularity, perfusion and hypoxia as well as for assessing cardiotoxicity.
Molecular imaging can be performed on the Vevo imaging system using two categories of contrast agents:
- Non-toxic, micron-sized agents which stay within the vasculature
- Sensitivity down to the capillary level
- Contrast agents can be targeted or untargeted
- Truly translational - used in the clinic
- Typically sub-100nm sized agents which can extravasate for tissue labeling
- Can be customized for a wide variety of targets and applications
- Can be multi-modal for PET, MR, Optical or other imaging compatability
Mouse Kidney Perfusion with Non-Targerted Microbubbles Imaged in Nonlinear Contrast Mode.
Tumor Perfusion with Non-Targerted Microbubbles, Imaged with Nonlinear Contrast and Displayed as MIP.
3D rendering of a photoacoustic image (overlaid onto B-Mode) of the mouse hind limb after Indocyanine Green (ICG) injection that migrated into the popliteal lymph node. Hind Limb vasculature can be seen in red and purple.
Displaying 36 - 40 of 262 results found
Multifunctional nanozyme for multimodal imaging-guided enhanced sonodynamic therapy by regulating the tumor microenvironment
Shuling Liu, Wei Zhang, Qiaoqi Chen, Jingxin Hou, Junrui Wang, Yixin Zhong, Xingyue Wang, Weixi Jiang, Haitao Ran, Dajing Guo
Nanoscale
.2021
;Contrast‑enhanced ultrasound molecular imaging of activated platelets in the progression of atherosclerosis using microbubbles bearing the von Willebrand factor A1 domain
Jie Tian, Yahui Weng, Ruiying Sun, Ying Zhu, Jun Zhang, Hongyun Liu, Yani Liu
Experimental and Therapeutic Medicine
.2021
;Early Detection and Reversal of Cell Apoptosis Induced by Focused Ultrasound-Mediated Blood-Brain Barrier Opening
Jieqiong Wang, Liting Xie, Yu Shi, Lijuan Ao, Feiyan Cai, Fei Yan
ACS Nano
.2021
;A multimodal molecular imaging approach targeting urokinase plasminogen activator receptor for the diagnosis, resection and surveillance of urothelial cell carcinoma
Victor M. Baart, Geertje van der Horst, Marion M. Deken, Shadhvi S. Bhairosingh, Timo Schomann, Vincent Q. Sier, Maaike H. van der Mark, Luisa Iamele, Hugo de Jonge, Massimo Resnati, Andrew P. Mazar, Rob C.M. Pelger, Gabriel van der Pluijm, Peter J.K. Kuppen, Alexander L. Vahrmeijer, Cornelis F.M. Sier
European Journal of Cancer
.2021
;Low-dose X-ray enhanced tumor accumulation of theranostic nanoparticles for high-performance bimodal imaging-guided photothermal therapy
Qiaolin Wei, Jian He, Shuaifei Wang, Shiyuan Hua, Yuchen Qi, Fangyuan Li, Daishun Ling, Min Zhou
Journal of Nanobiotechnology
.2021
;