The excellent spatial resolution and expanded functionality of the Vevo® high-frequency ultrasound system greatly facilitates reproductive biology researchers to visualize structures in male and female reproductive systems in small animal models ranging in size from zebra fish to rabbits.
High-spatial resolution up to 30 μm allows for excellent delineation of anatomy associated with reproductive biology research in 2D and 3D. Examples of reproductive organs that can be visualized in mice are: penis, prostate, testicle, epididymus, seminal vesicles, uterus, ovary, endometrium, placenta and mammary fat pad. Changes in any of these tissues caused by conditions such as cancer or pregnancy can be detected and quantified with the Vevo system.
Quantification of organ perfusion: Blood flow in the various male and reproductive organs can be detected and quantified at all vascular sizes. Pulsed-wave Doppler can obtain detailed velocity profiles in vessels such as testicular and ovarian artery. Color and Power Doppler can detect and quantify flow in the smaller vessels in the 100 μm and greater range. Contrast imaging with infusion of contrast agents can quantify flow down to the capillary level. Collectively these can provide a detailed hemodynamic assessment in the reproductive organs which can be followed longitudinally.
Image-guided injection and biopsy: The integrated rail system and the image-guided needle injection system enables needle injections to, and biopsies from, the prostate, ovary, or other reproductive organs without the need of a surgical incision. Examples of material injected can be cancer cells, stem cells or therapeutic compounds
Detection and quantification of biomarkers: Biomarker expressions can be detected and quantified using Target-ready Vevo MicroMarker contrast agents. For example, VEGF-R2-coupled Vevo MicroMarker contrast agents can be used as an angiogenesis marker in ovarian and prostate cancer.
Gene transfection and enhanced drug delivery: The SoniGene™ Gene & Drug Delivery System is a device used in conjunction with Vevo 2100 or Vevo 770 system along with injection of Vevo MicroMarker microbubbles. The SoniGene sends a pulse that disrupts microbubbles in the organ of interest. Within the process, sonoporation is induced. If gene products or drugs are mixed with the Vevo MicroMarker contrast agent infusions, enhanced gene transfection and drug delivery can be induced in the cells of the reproductive organs.
Sagittal Cervix and Endometrium.
Uterine Bifurcation.
Commonly used terminology:
uterus, ovary, mammary, testicle, endometriosis, placenta, OBGYN, obstetrics, breast, sperm, prostate
