Nanoparticles

Nanotechnology can be defined as manufactured materials and particles smaller than 100 nanometers in size.

With the ability to enter most cells, often without eliciting any immune response, nano-scale materials are designed to interact efficiently and precisely with biological materials. Their small size renders them the ability to enter areas of the body, such as the brain and individual cells, that have proved difficult to access with current technologies.

• Light absorption in the near-infrared range (750 nm – 2500 nm)
• For use with Vevo^® LAZR Photoacoustic Imaging System
• Biologically inactive for long in vivo circulation time
• Polyethylene glycol-coated for increased biocompatibility
• Gold nanorods for enhanced overall signal
• Single-walled carbon nanotubes for targeted imaging

Gold Nanorods

Gold nanorods are untargeted, contrast-enhancing agents which increase the endogenous vascular signal. They are important in many applications including cancer and drug delivery, and are highly customizable for conjugating to molecules of interest or directing bioactivity.

Nanopartz is the world’s largest supplier of gold nanoparticles for in vivo applications including Photoacoustic Imaging. Their patented and patent pending gold nanoparticles, including gold nanorods, are used throughout the world with over 3,000 customers in over 20 countries.

Single-Walled Carbon Nanotubes

Single-walled carbon nanotubes can be specifically targeted to cellular surface agents, receptors, proteins and molecules for identification of target factors.

Visualize tumors, including early stage growth, detect the location and estimate the concentration of cancers in vivo with targeted nanotubes:

• Argentine-gylcine-asparagine-conjugated SWNTs for targeting α-5,β-3 integrins which are over-expressed in tumor vasculature.
• Vascular endothelial growth factor receptor (VEGFR2) can be bound to nanoparticles.
• P-Selectin can be used as a cancer target when attached to nanoparticles.