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VisualSonics VevoStrain Technology Provides Earlier Access To Left Ventricular Dysfunctions

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Contacts:   VisualSonics: Shailja Tewari (416) 484-5000 x 5220
  SonoSite: Lisa Fritzky (425) 951-1375

A new dimension of diagnostic information:

Strain analysis feature of Vevo® 2100 high-frequency ultrasound system enables highly sensitive and rapid measurement of global (whole heart) and regional (specific heart areas) cardiac function.

TORONTO, Canada – April 14, 2011VisualSonics Inc., a leader in real-time, in vivo, high-resolution micro-imaging systems and a wholly-owned subsidiary of SonoSite Inc., announced today that its VevoStrain™ technology has been featured on the cover of the April 15th, 2011 issue of Circulation Research, Journal of the American Heart Association.

VevoStrain software provides advanced imaging and quantification capabilities to study sensitive movements in the heart muscles – specifically the myocardium. The VevoStrain technology augments high-resolution imaging capabilities of high-frequency ultrasound with highly sensitive measurements of subtle variations in the myocardium. The VevoStrain software enables tracking of wall motions in the heart, including the entire heart as well as defined regions within the heart. Measurement capabilities include quantification of displacement, velocity, strain and strain rate. Researchers at Brigham and Women’s Hospital, Harvard Medical School present the utility of VevoStrain technology as a non invasive, highly sensitive and rapid cardiac phenotyping tool in their seminal paper on in vivo strain analysis.

Dr Ronglih Liao, Associate Professor of Medicine, Harvard Medical School said, “We believe that, with strain analysis, we now have a very effective and efficient method for non-invasively detecting early cardiac performance irregularities in mice. While recognizing that this method requires special expertise and experience to implement, we are very excited about prospects for applying these analyses in future studies of experimental therapeutics.”

The VevoStrain software is emerging as the new state-of-the-art assessment tool for quantifying myocardial mechanical function and deformation, replacing Tissue Doppler imaging, which has been used in the past. Additional features of the software include measurement of cardiac wall motion abnormalities, dyssynchrony (delayed ventricular activation and contraction) and myocardial mechanics.

More information on VevoStrain software is available at: http://www.visualsonics.com/vevostrain

About VisualSonics

VisualSonics is the world leader in real time, in vivo, high-resolution micro imaging systems designed specifically for preclinical research and a wholly-owned subsidiary of SonoSite, Inc. (Nasdaq:Sono). The Company’s cutting edge technologies allow researchers at the world’s most prestigious pharmaceutical and biotechnology companies, hospitals and universities to conduct research in cardiovascular, cancer, neurobiology and developmental biology areas. The micro imaging technologies support research applications that include genetic research, phenotypic studies and drug development. VisualSonics micro imaging platforms combine high-resolution, real time in vivo imaging at reasonable cost with ease-of-use and quantifiable results.

About SonoSite

SonoSite, Inc. (www.sonosite.com) is the innovator and world leader in bedside and point-of-care ultrasound and an industry leader in ultra high-frequency micro-ultrasound technology and impedance cardiography equipment. Headquartered near Seattle, the company is represented by fourteen subsidiaries and a global distribution network in over 100 countries. SonoSite’s small, lightweight systems are expanding the use of ultrasound across the clinical spectrum by cost-effectively bringing high-performance ultrasound to the point of patient care.

Bauer M, Cheng S, Liao R; Echocardiographic Speckle-Tracking Based Strain Imaging for Rapid Cardiovascular Phenotyping in Mice; CIRCRESAHA/2010/239574-R1