Visualize early brain & spinal cord development, guided needle injections and extractions
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Because of its high-resolution imaging and the ability to provide real-time visualization, the Vevo system can visualize the development of early brain structures and spinal cord in utero and guide pulled glass needles for injections of cells, drugs, genetic material or metabolic agents into developing small animal embryos. The system can also be used for extraction procedures.
Many neurobiological applications including the study of embryonic and neonatal brain development, cell lineage and progressive neural degenerative diseases associated with small animal models can be complimented with the use of the Vevo high-resolution imaging system. The Vevo system successfully provides high-resolution images of the neonate mouse brain prior to ossification of the skull. Furthermore, structure and function of the adult brain can be visualized if a craniotomy is performed. Cerebral blood flow can also be visualized and quantified.
Monitoring of small animal brain development:
Due to the high-resolution images that can be derived, the neurobiologist can readily and reliably study embryonic and neonatal brain development. Furthermore, the non-invasive nature of the system allows for longitudinal study of the same animal without the need for contrast agents.
Visualization and quantification of cerebral blood flow:
For better assessment of disorders and angiogenesis studies.
Real-time image-guided needle injections and extractions:
Targeted needle injections of cells, genetic material, drugs and retroviruses can be visualized in real-time within small animals from embryonic to adult stages of development.
Easy to learn and obtain results:
The Vevo software is simple to use so that researchers can maximize their time performing post-imaging analysis. User friendly offline software is available to analyze all data. In addition, several on-line tutorials and protocols are available to allow researchers to learn quickly, analyze their data and obtain results.
Image guided Injection into fourth ventricle of a mouse brain E12. Imaged using B-Mode on Vevo 770 system.
Motor Cortex Injury Model vewed with Power Doppler to see slow blood flow. Imaged using Power Doppler Mode on Vevo 2100 system.
Motor Cortex Injury Model with Power Doppler where Yellow codes are for the highest blood quantity and velocity. Imaged using Power Doppler Mode on Vevo 2100 system.
Cortex blood flow seen earlier by Power Doppler but quantified by PW Doppler for Peak Velocities, Resistive and Pulsatility Indexes. Imaged using PW Doppler Mode on Vevo 2100 system.
Commonly used terminology:
brain, spinal cord, white matter, grey matter, cortex, hippocampu
