Applications - Cancer Research
Cytosolic Phospholipase A2 and Lysophospholipids in Tumor Angiogenesis
Amanda G. Linkous, Eugenia M. Yazlovitskaya, Dennis E. Hallahan Neuro-Oncology Branch, National Institutes of Health, Bethesda, MD (AGL); Division of Nephrology, Department of Medicine, and Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN (EMY); Alvin Siteman Cancer Center and Department of Radiation Oncology, Washington University in St Louis, St Louis, MO (DEH) Journal of the National Cancer Institute. 2010 Aug 20. [Epub ahead of print]  View Journal Brief
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Systemic Administration of Polymeric Nanoparticle-Encapsulated Curcumin (NanoCurc) Blocks Tumor Growth and Metastases in Preclinical Models of Pancreatic Cancer
Savita Bisht1, Masamichi Mizuma1, Georg Feldmann1,5, Niki A. Ottenhof1,6, Seung-Mo Hong1,2, Dipankar Pramanik1, Venugopal Chenna1, Collins Karikari1, Rajni Sharma1,2, Michael G. Goggins1,2,3,4, Michelle A. Rudek3, Rajani Ravi3, Amarnath Maitra7 and Anirban Maitra1,2,3 1 The Sol Goldman Pancreatic Cancer Research Center and Departments of 2 Pathology, 3 Oncology, and 4 Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; 5 Department of Internal Medicine III, Center of Integrated Oncology Cologne-Bonn, University of Bonn, Bonn, Germany; 6 Department of Pathology, University Medical Center, Utrecht, the Netherlands; and 7 Visvabharati University, Santiniketan, India Molecular Cancer Therapeutics. 2010 Jul 20. [Epub ahead of print] View Journal Brief
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p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal
Zhen Zhao1,2, Johannes Zuber1, Ernesto Diaz-Flores3, Laura Lintault1,4, Scott C. Kogan5, Kevin Shannon3 and Scott W. Lowe1,4 1 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA; 2 Genetics Program, Stony Brook University, Stony Brook, New York 11794, USA; 3 Department of Pediatrics, University of California at San Francisco, San Francisco, California 94143, USA; 4 Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA; 5 Department of Laboratory Medicine, University of California at San Francisco, San Francisco, California 94143, USA Genes & Development. 2010 Jul 1;24(13):1389-402 View Journal Brief
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Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer
David L. Schwartz1,2, James A. Bankson3, Robert Lemos, Jr.4, Stephen Y. Lai5, Arun K. Thittai1, Yi He1, Galen Hostetter6, Michael J. Demeure6, Daniel D. Von Hoff6, and Garth Powis5 Departments 1 Radiation Oncology, 2 Experimental Diagnostic Imaging, 3 Imaging Physics, and 4 Experimental Therapeutics, M.D. Anderson Cancer Center, Houston, Texas; 5 Head and Neck Surgery; and 6 TGEN, Phoenix, Arizona Molecular Cancer Therapeutics. 2010 Jul;9(7):2057-67. Epub 2010 Jun 29 View Journal Brief
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Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance
Olga B. Garbuzenko1, Maha Saad1, Vitaly P. Pozharov1, Kenneth R. Reuhl2,3,4, Gediminas Mainelis3,5, and Tamara Minko1,3,4 Departments of 1 Pharmaceutics, 2 Pharmacology and Toxicology, and 5 Environmental Sciences, Rutgers, The State University of New Jersey, Piscataway, NJ 08854; 3 Environmental and Occupational Health Sciences Institute, Piscataway, NJ 08855; and 4 Cancer Institute of New Jersey, New Brunswick, NJ 08903 Proceedings of the National Academy of Sciences of the United States of America. 2010 Jun 8;107(23):10737-42. Epub 2010 May 24 View Journal Brief
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Volume of Preclinical Xenograft Tumors Is More Accurately Assessed by Ultrasound Imaging Than Manual Caliper Measurements
Gregory D. Ayers, MS, Eliot T. McKinley, BSE, Ping Zhao, BS, Jordan M. Fritz, BS, Rebecca E. Metry, BS, Brenton C. Deal, BS, Katrina M. Adlerz, BS, Robert J. Coffey, MD and H. Charles Manning, PhD Departments of Biostatistics (G.D.A.), Biomedical Engineering (E.T.M., H.C.M.), Radiology and Radiological Sciences (H.C.M.), Medicine (R.J.C.), and Neurosurgery (H.C.M.), Vanderbilt University Institute of Imaging Science (E.T.M., P.Z., J.M.F., R.E.M., B.C.D., K.M.A., H.C.M.), and Program in Chemical and Physical Biology (H.C.M.), Vanderbilt University Medical Center, Nashville, Tennessee USA. Journal of Ultrasound in Medicine. 2010 Jun;29(6):891-901 View Journal Brief
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Antiangiogenic Cancer Therapy: Monitoring with Molecular US and a Clinically Translatable Contrast Agent (BR55)
Marybeth A. Pysz, PhD, Kira Foygel, PhD, Jarrett Rosenberg, PhD, Sanjiv S. Gambhir, MD, PhD, Michel Schneider, PhD and Jürgen K. Willmann, MD From the Department of Radiology, Molecular Imaging Program at Stanford (M.A.P., K.F., J.R., S.S.G., J.K.W.), and Department of Bioengineering (S.S.G.), Stanford University School of Medicine, 300 Pasteur Dr, Room H1307, Stanford, CA 94305; and Bracco Research, Geneva, Switzerland (M.S.). Radiology. 2010 Jun 1. [Epub ahead of print] View Journal Brief
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Serial Transcriptome Analysis and Cross-Species Integration Identifies Centromere-Associated Protein E as a Novel Neuroblastoma Target
Naomi J. Balamuth1, Andrew Wood1, Qun Wang1, Jayanti Jagannathan1, Patrick Mayes1, Zhe Zhang2, Zhongxue Chen2, Eric Rappaport3, Joshua Courtright1, Bruce Pawel4, Barbara Weber6, Richard Wooster6, Eric O. Sekyere7, Glenn M. Marshall7 and John M. Maris1,5 1 Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania 2 Center for Biomedical Informatics and 3 Department of Pediatrics, Children's Hospital of Philadelphia 4 Department of Pathology, Children's Hospital of Philadelphia and Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine 5 Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 6 GlaxoSmithKline, King of Prussia, Pennsylvania 7 Children's Cancer Institute Australia and Sydney Children's Hospital, Sydney, Australia Cancer Research. 2010 Apr 1;70(7):2749-58. Epub 2010 Mar 16 View Journal Brief
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Correlation Between 2- and 3-Dimensional Assessment of Tumor Volume and Vascular Density by Ultrasonography in a Transgenic Mouse Model of Mammary Carcinoma
Lei Zhao, PhD, Yutian Zhan, MS, J. Lynn Rutkowski, PhD, Giora Z. Feuerstein, MD and Xinkang Wang, PhD Discovery Translational Medicine, Wyeth Research, 500 Arcola Rd, Collegeville, PA 19426, USA Journal of Ultrasound in Medicine. 2010 Apr;29(4):587-95 View Journal Brief
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Correlation of Quantified Contrast-Enhanced Sonography With In Vivo Tumor Response
Misun Hwang, BS, Ghazal Hariri, MS, Andrej Lyshchik, MD, PhD, Dennis E. Hallahan, MD and Arthur C. Fleischer, MD Vanderbilt University School of Medicine (M.H.) and Departments of Radiology and Radiological Sciences (A.L., A.C.F.) and Radiation Oncology (G.H., D.E.H.), Vanderbilt University Medical Center, Nashville, Tennessee USA Journal of Ultrasound in Medicine. 2010 Apr;29(4):597-607 View Journal Brief
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Lipid membrane editing with peptide cargo linkers in cells and synthetic nanostructures
Hua Pan, Jacob W. Myerson, Olena Ivashyna, Neelesh R. Soman, Jon N. Marsh, Joshua L. Hood, Gregory M. Lanza, Paul H. Schlesinger, and Samuel A. Wickline Department of Medicine,Department of Biomedical Engineering, and Department of Molecular Cell Biology, Washington University School of Medicine, St. Louis, Missouri, USA The FASEB Journal. 2010 Mar 24. [Epub ahead of print] View Journal Brief
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Targeted Contrast-Enhanced Ultrasound Imaging of Tumor Angiogenesis with Contrast Microbubbles Conjugated to Integrin-Binding Knottin Peptides
Jürgen K. Willmann 1, Richard H. Kimura 2, Nirupama Deshpande 1, Amelie M. Lutz 1, Jennifer R. Cochran 3, and Sanjiv S. Gambhir 2 1 Molecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, Stanford, California 2 Molecular Imaging Program at Stanford, Department of Radiology, School of Medicine, Stanford University, Stanford, California; Department of Bioengineering, School of Medicine, Stanford University, Stanford, California 3 Department of Bioengineering, School of Medicine, Stanford University, Stanford, California The Journal of Nuclear Medicine. 2010 Mar;51(3):433-40. Epub 2010 Feb 11 View Journal Brief
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IFN-ß Restricts Tumor Growth and Sensitizes Alveolar Rhabdomyosarcoma to Ionizing Radiation
Thomas L. Sims1,4, Mackenzie McGee1, Regan F. Williams1,4, Adrianne L. Myers1,4, Lorraine Tracey1, J. Blair Hamner1,4, Catherine Ng1, Jianrong Wu2, M. Waleed Gaber5, Beth McCarville3, Amit C. Nathwani6 and Andrew M. Davidoff1,4 Departments of 1Surgery, 2Biostatistics, and 3Radiologic Sciences, St. Jude Children's Research Hospital; Departments of 4Surgery and 5Biomedical Engineering, University of Tennessee Health Science Center, Memphis, Tennessee and 6Department of Hematology/Oncology, University College, London, United Kingdom Molecular Cancer Therapeutics. 2010 Mar;9(3):761-71. Epub 2010 Mar 2 View Journal Brief
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Paracrine Regulation of Pancreatic Cancer Cell Invasion by Peripheral Nerves
Ziv Gil, Oren Cavel, Kaitlyn Kelly, Peter Brader, Avigail Rein, Sizhi P. Gao, Diane L. Carlson, Jatin P. Shah, Yuman Fong, Richard J. Wong The Laboratory for Applied Cancer Research, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel (ZG, OC, AR); Department of Surgery (ZG, KK, AR, JPS, PB, YF, RJW), Department of Medicine (SPG), and Department of Pathology (DLC), Memorial Sloan-Kettering Cancer Center, New York, NY; Department of Radiology, Division of Pediatric Radiology, Medical University Graz, Austria (PB) Journal of the National Cancer Institute. 2010 Jan 12. [Epub ahead of print] View Journal Brief
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Quantifying Antivascular Effects of Monoclonal Antibodies to Vascular Endothelial Growth Factor: Insights from Imaging
James P.B. O'Connor1,2, Richard A.D. Carano3, Andrew R. Clamp2, Jed Ross3, Calvin C.K. Ho3, Alan Jackson1, Geoff J.M. Parker1, Chris J. Rose1, Franklin V. Peale4, Michel Friesenhahn5, Claire L. Mitchell1,2, Yvonne Watson1, Caleb Roberts1, Lynn Hope2, Sue Cheung1, Hani Bou Reslan3, Mary Ann T. Go6, Glenn J. Pacheco6, Xiumin Wu7, Tim C. Cao3, Sarajane Ross6, Giovanni A. Buonaccorsi1, Karen Davies1, Jurjees Hasan2, Paula Thornton2, Olivia del Puerto8, Napoleone Ferrara7, Nicholas van Bruggen3 and Gordon C. Jayson2 1 Imaging Science and Biomedical Engineering, School of Cancer and Imaging Sciences, University of Manchester and 2 Cancer Research UK and University of Manchester Department of Medical Oncology, Christie Hospital, Manchester, United Kingdom 3 Biomedical Imaging Group, Department of Tumor Biology and Angiogenesis, Departments of 4 Pathology, 5 Biostatistics, 6 Translational Oncology and 7 Ferrara Laboratory, Genentech, Inc., South San Francisco, California; and 8 Roche Products Limited, Hertfordshire, United Kingdom Clinical Cancer Research. 2009 Nov 2; 15(21):6674–82 View Journal Brief
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In vivo, Noninvasive, Label-Free Detection and Eradication of Circulating Metastatic Melanoma Cells Using Two-Color Photoacoustic Flow Cytometry with a Diode Laser
Ekaterina I. Galanzha 1, 2, Evgeny V. Shashkov 1, Paul M. Spring 2, James Y. Suen 2, and Vladimir P. Zharov 1, 2 1 Phillips Classic Laser and Nanomedicine Laboratories 2 Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas Cancer Research. 2009 Oct 15;69(20):7926-34. Epub 2009 Oct 13 View Journal Brief
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Morphological ultrasound micro-imaging of thyroid in living mice
Marcello Mancini, Emilia Vergara, Giuliana Salvatore, Adelaide Greco, Giancarlo Troncone, Andrea Affuso, Raffaele Liuzzi, Paolo Salerno, Maria Scotto di Santolo, Massimo Santoro, Arturo Brunetti, and Marco Salvatore Institute of Biostructure and Bioimaging, Italian National Research Council (CNR), Naples, Italy; SDN Foundation IRCCS, Naples, Italy; Department of Biomorphological and Functional Sciences, Universita' "Federico II" Naples, Italy; Dipartimento di Studi delle Istituzioni e dei Sistemi Territoriali, Università "Parthenope", Naples, Italy; CEINGE-Biotecnologie Avanzate s.c.a.r.l., Naples, Italy; Biogem (Biologia e genetica molecolare) Ariano Irpino, Avellino, Italy; Dipartimento di Biologia e Patologia Cellulare e Molecolare "L. Califano", Università "Federico II", Naples, Italy Endocrinology. 2009 Oct;150(10):4810-5. Epub 2009 Jul 9 View Journal Brief
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Inhibition of Hsp90 via 17-DMAG induces apoptosis in a p53-dependent manner to prevent medulloblastoma
Olivier Ayrault1, Michael D. Godeny2, Christopher Dillon2, Frederique Zindy1, Patrick Fitzgerald2, Martine F. Roussel1 and Helen M. Beere2 Departments of 1Genetics and Tumor Cell Biology and 2Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105 Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2009 Oct 6;106(40):17037-42. Epub 2009 Sep 23 View Journal Brief
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Inhibition of Tumor Growth Progression by Antiandrogens and mTOR Inhibitor in a Pten-Deficient Mouse Model of Prostate Cancer
Weisheng Zhang 1, Joe Zhu 1, Clay L. Efferson 2, Chris Ware 3, Jennifer Tammam 2, Minilik Angagaw 4, Jason Laskey 2, Kimberly A. Bettano 1, Shailaja Kasibhatla 2, John F. Reilly 3, Cyrille Sur 5, and Pradip K. Majumder 2 Departments of 1Imaging, 2Oncology, 3Pharmacology, and 4Laboratory Animal Research, Merck Research Laboratories, Boston, Massachusetts; and 5Imaging Department, Merck Research Laboratories, West Point, Pennsylvania Cancer Research. 2009 Sep 15;69(18):7466-72. Epub 2009 Sep 8 View Journal Brief
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Tumor Vascular Changes Mediated by Inhibition of Oncogenic Signaling
Naseer Qayum 1, Ruth J. Muschel 1, Jae Hong Im 1, Lukxmi Balathasan 1, Cameron J. Koch 2, Sonal Patel 3, W. Gillies McKenna 1, and Eric J. Bernhard 1 1 Gray Institute for Radiation Oncology and Biology, Oxford University, Oxford, United Kingdom 2 Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 3 PIramed Pharma, Slough, United Kingdom Cancer Research. 2009 Aug 1;69(15):6347-54. Epub 2009 Jul 21 View Journal Brief
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Prostate-specific Klf6 Inactivation Impairs Anterior Prostate Branching Morphogenesis through Increased Activation of the Shh Pathway
Ching Ching Leow1, Bu-er Wang1, Jed Ross2, Sara M. Chan3, Jiping Zha3, Richard A. D. Carano2, Gretchen Frantz3, Michael M. Shen4, Frederic J. de Sauvage1, and Wei-Qiang Gao1 From the From the Departments of 1Molecular Biology, 2Tumor Biology and Angiogenesis, and , 3Pathology, Genentech Inc., South San Francisco, California 94080 and , the 4Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York 10032 The Journal of biological chemistry. 2009 Jul 31;284(31):21057-65. Epub 2009 Jun 3 View Journal Brief
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Coregistration of ultrasonography and magnetic resonance imaging with a preliminary investigation of the spatial colocalization of vascular endothelial growth factor receptor 2 expression and tumor perfusion in a murine tumor model
Mary E. Loveless, Jennifer G. Whisenant, Kevin Wilson, Andrej Lyshchik, Tuhin K. Sinha, John C. Gore, Thomas E. Yankeelov Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee 37232-2675, USA Molecular Imaging. 2009 Jul-Aug;8(4):187-98 View Journal Brief
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Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer
Kenneth P. Olive 1, Michael A. Jacobetz 1, Christian J. Davidson 2, Aarthi Gopinathan 3, Dominick McIntyre 1, Davina Honess 1, Basetti Madhu 1, Mae A. Goldgraben 1, Meredith E. Caldwell 1, David Allard 1, Kristopher K. Frese 1, Gina DeNicola 3, Christine Feig 1, Chelsea Combs 2, Stephen P. Winter 1, Heather Ireland 1, Stefanie Reichelt 1, William J. Howat 1, Alex Chang 4, Mousumi Dhara 4, Lifu Wang 5, Felix Rückert 6, Robert Grützmann 6, Christian Pilarsky 6, Kamel Izeradjene 7, Sunil R. Hingorani 7, Pearl Huang 8, Susan E. Davies 9, William Plunkett 10, Merrill Egorin 11, Ralph H. Hruban 4, Nigel Whitebread 12, Karen McGovern 12, Julian Adams 12, Christine Iacobuzio-Donahue 4, John Griffiths 1, David A. Tuveson 1 1 Cancer Research UK, Cambridge Research Institute, The Li Ka Shing Centre, Robinson Way, Cambridge, CB2 ORE, UK. 2 Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. 3 Cancer Research UK, Cambridge Research Institute, The Li Ka Shing Centre, Robinson Way, Cambridge, CB2 ORE, UK.; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA. 4 Departments of Oncology and Pathology, The Sol Goldman Pancreatic Cancer Research Center, Sidney Cancer Center and Johns Hopkins University, Baltimore, MD 21287, USA. 5 Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Gastroenterology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. 6 Department of Surgery, University Hospital Dresden, Fetscherstr. 74, 01307 Dresden, Germany. 7 Clinical Research and Public Health Sciences Division, Fred Hutchinson Cancer Research Center, and University of Washington, Seattle, WA 98109, USA. 8 Oncology Franchise, Merck and Co, North Wales, PA 19454, USA. 9 Department of Histopathology, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 2QQ, UK. 10 Univ. of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. 11 Division of Hematology and Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA. 12 Infinity Pharmaceuticals Inc, Cambridge, MA 01239, USA. Sciencexpress. 2009 Jun 12;324(5933):1457-61. Epub 2009 May 21 View Journal Brief
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Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model
Cedo M. Bagi,1 James Christensen,2 Darrel P. Cohen,2 Walter G. Roberts,3 Dean Wilkie,4 Terri Swanson,1 Theresa Tuthill5 and Catharine J. Andresen1 1 Global Science & Technology; and 4 Investigative Pathology; PGRD; Pfizer, Inc.; Groton, CT USA; 2 Oncology; PGRD; Pfizer Inc; La Jolla, CA USA; 3 Safety and Risk Management; and 5 Molecular Medicine; PGRD; Pfizer Inc; New London, CT USA Cancer Biology & Therapy. 2009 May;8(9):856-65 View Journal Brief
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Complementarity of ultrasound and fluorescence imaging in an orthotopic mouse model of pancreatic cancer
Cynthia S Snyder1 , Sharmeela Kaushal1 , Yuko Kono2 , Hop S Tran Cao3 , Robert M Hoffman3,4 and Michael Bouvet1,3 1 Moores UCSD Cancer Center, University of California, La Jolla, CA, USA 2 UCSD Department of Medicine, La Jolla, CA, USA 3 UCSD Department of Surgery, La Jolla, CA, USA 4 AntiCancer Inc., San Diego, CA, USA BMC Cancer. 2009 Apr 8;9(1):106. [Epub ahead of print] View Journal Brief
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The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects
David L. Schwartz1,2, Garth Powis3, Arun Thitai-Kumar2, Yi He1, James Bankson4, Ryan Williams3, Robert Lemos3, Junghwan Oh1, Andrei Volgin2, Suren Soghomonyan2, Ryuichi Nishii2, Mian Alauddin2, Uday Mukhopadhay2, Zhenghong Peng3, William Bornmann3 and Juri Gelovani2 Departments of 1Radiation Oncology, 2Experimental Diagnostic Imaging, 3Experimental Therapeutics, and 4Imaging Physics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas Molecular Cancer Therapeutics. 2009 Apr 1; 8(4):947–58 View Journal Brief
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Effective prostate cancer chemopreventive intervention with green tea polyphenols in the TRAMP model depends on the stage of the disease
Vaqar Mustafa Adhami, Imtiaz Ahmad Siddiqui, Sami Sarfaraz, Sabih Islam Khwaja, Bilal Bin Hafeez, Nihal Ahmad and Hasan Mukhtar Department of Dermatology, University of Wisconsin-Madison, WI 53706 Clinical Cancer Research. 2009 Mar 15;15(6):1947-53. Epub 2009 Mar 10 View Journal Brief
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Quantitative Ultrasound Characterization of Responses to Radiotherapy in Cancer Mouse Models
Roxana M. Vlad 1, 3, Sebastian Brand 5, Anoja Giles 3, Michael C. Kolios 1, 4, Gregory J. Czarnota 1, 2, 3 Authors' Affiliations: Departments of 1Medical Biophysics and 2Radiation Oncology, University of Toronto, 3Sunnybrook Health Sciences Centre, and 4Department of Physics, Ryerson University, Toronto, Ontario, Canada; and 5Orthopedics Department, Q-BAM Laboratory, University of Halle, Halle, Germany Clinical Cancer Research. 2009 Mar 15;15(6):2067-75. Epub 2009 Mar 10 View Journal Brief
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Cytosolic Phospholipase A2: Targeting Cancer through the Tumor Vasculature
Amanda Linkous, Ling Geng, Andrej Lyshchik, Dennis E. Hallahan, Eugenia M. Yazlovitskaya Departments of 1Radiation Oncology, 2Cancer Biology, 3Radiology and Radiological Sciences, and 4Cell and Developmental Biology, and 5Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee Clinical Cancer Research. 2009 Mar 1;15(5):1635-44. Epub 2009 Feb 24 View Journal Brief
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Suppression of Tumor Growth In vivo by the Mitocan {alpha}-tocopheryl Succinate Requires Respiratory Complex II
Lan-Feng Dong, Ruth Freeman, Ji Liu, Renata Zobalova, AlvaroMarin-Hernandez, Marina Stantic, Jakub Rohlena, Karel Valis, Sara Rodriguez-Enriquez, Bevan Butcher, Jacob Goodwin, Ulf T. Brunk, Paul K. Witting, RafaelMoreno-Sanchez, Immo E. Scheffler, Stephen J. Ralph, and Jiri Neuzil Authors' Affiliations: Apoptosis Research Group and Genomic Research Centre, School of Medical Science, Griffith University, Southport, Queensland, Australia; Molecular Therapy Group, Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague, Czech Republic; Department of Biochemistry, National Institute of Cardiology, Mexico City, Mexico; Division of Pharmacology, University of Linkoping, Linkoping, Sweden; ANZAC Research Institute, Concord Hospital, Concord, Sydney, New South Wales, Australia; and Division of Biology, University of California, San Diego, California. Clinical Cancer Research 2009 Mar 1;15(5):1593-600. Epub 2009 Feb 17 View Journal Brief
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A Method for Assessing the Microvasculature in a Murine Tumor Model Using Contrast-Enhanced Ultrasonography
Mary E. Loveless, MS, Xia Li, PhD, Jessica Huamani, MS, Andrej Lyshchik, MD, PhD, Benoit Dawant, PhD, Dennis Hallahan, MD, John C. Gore, PhD, Thomas E. Yankeelov, PhD Institute of Imaging Science (M.E.L., X.L., B.D., J.C.G., T.E.Y.) and Departments of Biomedical Engineering (M.E.L., D.H., J.C.G., T.E.Y.), Electrical Engineering and Computer Science (X.L., B.D.), Radiation Oncology (J.H., D.H.), Radiology and Radiological Sciences (A.L., J.C.G., T.E.Y.), Physics and Astronomy (J.C.G., T.E.Y.), and Cancer Biology (T.E.Y.), Vanderbilt University, Nashville, Tennessee USA Journal of ultrasound in medicine. 2008 Dec; 27(12):1699-709 View Journal Brief
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Interstitial Doppler Optical Coherence Tomography as a Local Tumor Necrosis Predictor in Photodynamic Therapy of Prostatic Carcinoma: An In vivo Study
Beau A. Standish, Kenneth K.C. Lee, Xiao Jin, Adrian Mariampillai, Nigel R. Munce, Michael F.G. Wood, Brian C. Wilson, I. Alex Vitkin, and Victor X.D. Yang Department of Medical Biophysics and Radiation Oncology, University of Toronto, Ontario Cancer Institute/University Health Network, Department Electrical and Computer Engineering, Ryerson University, and Imaging Research, Sunnybrook Health Sciences Center, Toronto, Canada Cancer Research. 2008 Dec 1;68(23):9987-95 View Journal Brief
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ODC1 Is a Critical Determinant of MYCN Oncogenesis and a Therapeutic Target in Neuroblastoma
Michael D. Hogarty1,2, Murray D. Norris5, Kimberly Davis1, Xueyuan Liu1, Nicholas F. Evageliou1, Candace S. Hayes7, Bruce Pawel3, Rong Guo4, Huaqing Zhao4, Eric Sekyere5, Joanna Keating5, Wayne Thomas5, Ngan Ching Cheng5, Jayne Murray5, Janice Smith5, Rosemary Sutton5, Nicola Venn5, Wendy B. London8, Allen Buxton8, Susan K. Gilmour7, Glenn M. Marshall5,6 and Michelle Haber5 1 Division of Oncology, The Children's Hospital of Philadelphia; Departments of 2 Pediatrics, 3 Pathology, and 4 Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania; 5 Children's Cancer Institute Australia for Medical Research; 6 Centre for Children's Cancer and Blood Disorders, Sydney Children's Hospital, Randwick, New South Wales, Australia; 7 Lankenau Institute for Medical Research, Wynnewood, Pennsylvania; and 8 Department of Statistics, University of Florida and Children's Oncology Group Statistics and Data Center Department, Gainesville, Florida Cancer Research. 2008 Dec 1;68(23):9735-45 View Journal Brief
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Molecular Imaging of Therapeutic Response to Epidermal Growth Factor Receptor Blockade in Colorectal Cancer
H. Charles Manning, Nipun B. Merchant, A. Coe Foutch, John M. Virostko, Shelby K. Wyatt, Chirayu Shah, Eliot T. McKinley, Jingping Xie, Nathan J. Mutic, M. Kay Washington, Bonnie LaFleur, Mohammed Noor Tantawy, Todd E. Peterson, M. Sib Ansari, Ronald M. Baldwin, Mace L. Rothenberg, Darryl J. Bornhop, John C. Gore, and Robert J. Coffey 1Vanderbilt Institute of Imaging Science, Departments of 2Radiology and Radiological Sciences, 3Neurological Surgery, 4Surgery, 5Pathology, and 6Biostatistics, and 7Program in Chemical and Physical Biology, Vanderbilt University Medical Center; Departments of 8Biomedical Engineering, 9Chemistry, and 10Cell and Developmental Biology, Vanderbilt University; 11Department of Medicine,Vanderbilt University Medical School; 12Department of Veterans AffairsMedical Center, Nashville,Tennessee Clin. Cancer Res. 2008 Nov 15;14(22):7413-22 View Journal Brief
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Early therapy evaluation of combined anti-death receptor 5 antibody and gemcitabine in orthotopic pancreatic tumor xenografts by diffusion-weighted magnetic resonance imaging
Kim H, Morgan DE, Buchsbaum DJ, Zeng H, Grizzle WE, Warram JM, Stockard CR, McNally LR, Long JW, Sellers JC, Forero A, Zinn KR. Department of Radiology, University of Alabama at Birmingham, Birmingham, Alabama 35294-0012, USA Cancer Research. 2008 Oct 15;68(20):8369-76. View Journal Brief
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Ultrasound imaging of apoptosis in tumor response: novel preclinical monitoring of photodynamic therapy effects
Banihashemi B, Vlad R, Debeljevic B, Giles A, Kolios MC, Czarnota GJ. Department of Radiation Oncology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada Cancer Research. 2008 Oct 15;68(20):8590-6. View Journal Brief
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Biomedical imaging in the safety evaluation of new drugs
Yi-Xiang J Wang and Sen-Xiang Yan Department of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China; Department of Radiation Oncology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China Laboratory Animals. 2008 Oct;42(4):433-41. View Journal Brief
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Targeted Microbubbles for Imaging Tumor Angiogenesis: Assessment of Whole-Body Biodistribution with Dynamic Micro-PET in Mice
Jürgen K. Willmann, MD; Zhen Cheng, PhD; Corrine Davis, DVM, PhD; Amelie M. Lutz, MD; Meike L. Schipper, MD; Carsten H. Nielsen, BS; Sanjiv S. Gambhir, MD, PhD Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program (J.K.W., Z.C., A.M.L., M.L.S., C.H.N., S.S.G.), Department of Comparative Medicine (C.D.), and Department of Bioengineering (S.S.G.), Stanford University School of Medicine, James H. Clark Center, 318 Campus Dr, East Wing, 1st Floor, Stanford, CA 94305-5427 Radiology. 2008 Oct; 249(1): 212-9 View Journal Brief
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An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer
Georg Feldmann,, Volker Fendrich, Karen McGovern, Djahida Bedja, Savita Bisht, Hector Alvarez,, Jan-Bart M. Koorstra, Nils Habbe,, Collins Karikari, Michael Mullendore,, Kathleen L. Gabrielson, Rajni Sharma, William Matsui, and Anirban Maitra Departments of Pathology, Comparative Medicine, Oncology, and Surgery, and The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland and Infinity Pharmaceuticals, Cambridge, Massachusetts Molecular Cancer Therapeutics. 2008 Sep; 7(9):2725-35 View Journal Brief
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Dual-targeted Contrast Agent for US Assessment of Tumor Angiogenesis in Vivo
Jürgen K. Willmann, MD; Amelie M. Lutz, MD; Ramasamy Paulmurugan, PhD; Manishkumar R. Patel, PhD; Pauline Chu, BA; Jarrett Rosenberg, PhD; Sanjiv S. Gambhir, MD, PhD Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program (J.K.W., A.M.L., R.P., M.R.P., J.R., S.S.G.) and Department of Bioengineering (S.S.G.), Stanford University School of Medicine, the James H Clark Center, 318 Campus Dr, East Wing, 1st Floor, Stanford, CA 94305-5427; and Department of Comparative Medicine, Stanford University, Stanford, Calif (P.C.) Radiology. 2008 Sep;248(3):936-44 View Journal Brief
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Vessel Fractions in Tumor Xenografts Depicted by Flow- or Contrast-Sensitive Three-Dimensional High-Frequency Doppler Ultrasound Respond Differently to Antiangiogenic Treatment
Moritz Palmowski, Jochen Huppert, Peter Hauff, Michael Reinhardt, Karin Schreiner, Michaela A. Socher, Peter Hallscheidt, Guenter W. Kauffmann, Wolfhard Semmler, and Fabian Kiessling Medical Physics in Radiology, German Cancer Research Center; Division of Experimental Molecular Imaging, RWTH-Aachen University, Aachen, Germany; Global Drug Discovery, Bayer Schering Pharma AG, Berlin, Germany; and Department of Diagnostic Radiology, University of Heidelberg, Heidelberg, Germany Cancer Research. 2008 Sep 1;68(17):7042-9 View Journal Brief
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Imaging Hypoxia in Orthotopic Rat Liver Tumors with Iodine 124-labeled Iodoazomycin Galactopyranoside PET
Christopher C. Riedl,MD; Peter Brader,MD; Pat B. Zanzonico, PhD; Yun Shin Chun,MD; Yanghee Woo, MD; Paramjeet Singh, MD; Sean Carlin, PhD; Bixiu Wen,MD; C. Clifton Ling, PhD; Hedvig Hricak,MD; Yuman Fong, MD Departments of Radiology (C.C.R., P.B., H.H.), Medical Physics (P.B.Z., S.C., B.W., C.C.L.), and Surgery (Y.S.C., Y.W., P.S., Y.F.), Memorial Sloan-Kettering Cancer Center, 1275 York Ave, Room C-278, New York, NY 10021. Radiology. 2008 Aug;248(2):561-70 View Journal Brief
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Attenuated multimutated herpes simplex virus-1 effectively treats prostate carcinomas with neural invasion while preserving nerve function
Kelly K, Brader P, Rein A, Shah JP, Wong RJ, Fong Y, Gil Z Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA The Journal of the Federation of American Societies for Experimental Biology. 2008 Jun;22(6):1839-48. View Journal Brief
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MetMAb, the one-armed 5D5 anti-c-Met antibody, inhibits orthotopic pancreatic tumor growth and improves survival
Jin H, Yang R, Zheng Z, Romero M, Ross J, Bou-Reslan H, Carano RA, Kasman I, Mai E, Young J, Zha J, Zhang Z, Ross S, Schwall R, Colbern G, Merchant M Department of Translational Oncology, Genentech, Inc., South San Francisco, California 94080, USA Cancer Research. 2008 Jun 1;68(11):4360-8. View Journal Brief
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Volumetric high-frequency Doppler ultrasound enables the assessment of early antiangiogenic therapy effects on tumor xenografts in nude mice
Jugold M, Palmowski M, Huppert J, Woenne EC, Mueller MM, Semmler W, Kiessling F. German Cancer Research Center, Heidelberg, Germany. Eur Radiol. 2008 Apr;18(4):753-8. Epub 2007 Dec 15 View Journal Brief
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Urocortin2 inhibits tumor growth via effects on vascularization and cell proliferation
Zhengrong Hao, Yan Huang, Jake Cleman, Ion S. Jovin, Wylie W. Vale, Tracy L. Bale, and Frank J. Giordano Department of Medicine, Yale University, New Haven, CT 06520; Peptide Biology Laboratories, Salk Institute, La Jolla, CA 92037; and Department of Animal Biology, University of Pennsylvania, Philadelphia, PA 19104 Proceedings of the National Academy of Sciences. 2008 March 11;105(10): 3939-3944 View Journal Brief
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Mitogen-activated protein kinase kinase signaling promotes growth and vascularization of fibrosarcoma
Yan Ding, Elissa A. Boguslawski, Bree D. Berghuis, John J. Young, Zhongfa Zhang, Kim Hardy, Kyle Furge, Eric Kort, Arthur E. Frankel, Rick V. Hay, James H. Resau and Nicholas S. Duesbery Laboratories of Cancer and Developmental Cell Biology, Analytical, Cellular and Molecular Microscopy, Cancer Genetics, Noninvasive Imaging and Radiation Biology, and Computational Biology, Van Andel Research Institute, Grand Rapids, Michigan and 6 Cancer Research Institute of Scott & White Memorial Hospital, Temple, Texas Molecular Cancer Therapeutics. 2008 March 1;7: 648-658. View Journal Brief
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{alpha}2{beta}1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor cell-specific manner
Zhang Z, Ramirez NE, Yankeelov TE, Li Z, Ford LE, Qi Y, Pozzi A, Zutter MM Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN 37232-2561, USA Blood. 2008 Feb 15;111(4):1980-8. View Journal Brief
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US Imaging of Tumor Angiogenesis with Microbubbles Targeted to Vascular Endothelial Growth Factor Receptor Type 2 in Mice
Jürgen K. Willmann, MD; Ramasamy Paulmurugan, PhD; Kai Chen, PhD; Olivier Gheysens, MD; Martin Rodriguez-Porcel, MD; Amelie M. Lutz, MD; Ian Y. Chen, MSE; Xiaoyuan Chen, PhD; Sanjiv S. Gambhir, MD, PhD Molecular Imaging Program at Stanford, Department of Radiology and Bio-X Program (J.K.W., R.P., K.C., O.G., M.R., A.M.L., I.Y.C., X.C., S.S.G.), and Department of Bioengineering (I.Y.C., S.S.G.), Stanford University School of Medicine, the James H. Clark Center, 318 Campus Dr, East Wing, 1st Floor, Stanford, CA 94305-5427 Radiology. 2008 Feb; 246(2):508-18. Epub 2008 Jan 7 View Journal Brief
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Measurement of Human Choroidal Melanoma Xenograft Volume in Rats Using High-Frequency Ultrasound
Rod D. Braun and Kerry S. Vistisen Department of Anatomy and Cell Biology and the Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan Investigative Ophthalmology and Visual Science. 2008 Jan;49(1):16-22 View Journal Brief
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Vitamin E analogues inhibit angiogenesis by selective induction of apoptosis in proliferating endothelial cells: the role of oxidative stress
Lan-Feng Dong, Emma Swettenham, Johanna Eliasson, Xiu-Fang Wang, Mikhal Gold, Yasmine Medunic, Marina Stantic, Pauline Low, LubomirPr ochazka, Paul K. Witting, Jaroslav Turanek, Emmanuel T. Akporiaye, Stephen J. Ralph, and Jiri Neuzil Apoptosis Research Group, School of Medical Science, Griffith University, Southport, Queensland, Australia. Cancer Research. 2007 Dec 15;67(24):11906-13. View Journal Brief
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TRA-8 anti-DR5 monoclonal antibody and gemcitabine induce apoptosis and inhibit radiologically validated orthotopic pancreatic tumor growth
Derosier LC, Vickers SM, Zinn KR, Huang Z, Wang W, Grizzle WE, Sellers J, Stockard CR Jr, Zhou T, Oliver PG, Arnoletti P, Lobuglio AF, Buchsbaum DJ. University of Alabama at Birmingham, 1530 3rd Avenue South, Wallace Tumor Institute 674, Birmingham, AL Mol Cancer Ther. 2007 Dec;6(12):3198-207. View Journal Brief
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Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma
Theofilos Poutahidis1,5, Kevin M. Haigis2,6, Varada P. Rao1, Prashant R. Nambiar1, Christie L. Taylor1, Zhongming Ge1, Koichiro Watanabe1, Anne Davidson3,7, Bruce H. Horwitz4, James G. Fox1 and Susan E. Erdman1 1 Division of Comparative Medicine; 2 Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA; 3 Department of Medicine and Microbiology, Columbia University, 1130 St Nicholas Avenue, Room 918, New York, NY 10032; 4 Immunology Research Division, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA; 5 Present address: Laboratory of Pathology, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki 54006, Greece; 6 Present address: Unit for Molecular Pathology, Center for Cancer Research, Massachusetts General Hospital, Bldg 149, Rm 7148, 13th Street, Charlestown, MA 02129, USA; 7 Present address: Feinstein Institute for Medical Research, 350 Community Drive, Manhasset NY 11030, USA Carcinogenesis. 2007 Dec;28(12):2614-23. Epub 2007 Aug 27 View Journal Brief
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Molecular Imaging Of Vascular Endothelial Growth Factor Receptor 2 Expression Using Targeted Contrast-Enhanced High-Frequency Ultrasonography
Lyshchik A, Fleischer AC, Huamani J, Hallahan DE, Brissova M, Gore JC Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN J Ultrasound Med. 2007 Nov;26(11):1575-86. View Journal Brief
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Imaging of hypoxia-driven gene expression in an orthotopic liver tumor model
Peter Brader1, Christopher Cesare Riedl1, Yanghee Woo2, Vladimir Ponomarev1, Pat Zanzonico3, Bixiu Wen3, Shangde Cai4, Hedvig Hricak1, Yuman Fong2, Ronald Blasberg1,5 and Inna Serganova5 Departments of 1 Radiology, 2 Surgery, and 3 Medical Physics; 4 Cyclotron and Radiochemistry Core Facility; and 5 Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York, New York Molecular Cancer Therapeutics. 2007 Nov;6(11):2900-8. Epub 2007 Nov 7 View Journal Brief
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Ovarian Volume Measurements in Mice With High-Resolution Ultrasonography
Andrej Lyshchik, MD, PhD, Stephen B. Hobbs, Arthur C. Fleischer, MD, Dineo Khabele, MD, Deok-Soo Son, DVM, PhD, John C. Gore, PhD and Ronald R. Price, PhD Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee USA (A.L., S.B.H., A.C.F., J.C.G., R.R.P.); Vanderbilt University Institute of Imaging Science, Nashville, Tennessee USA (A.L., J.C.G.); and Department of Obstetrics and Gynecology, Meharry Medical College, Nashville, Tennessee USA (D.K., D.-S.S.). J Ultrasound Med. 2007 Oct; 26(10), PP 1419-1425 View Journal Brief
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Microultrasound Molecular Imaging of Vascular Endothelial Growth Factor Receptor 2 in a Mouse Model of Tumor Angiogenesis
Joshua J. Rychak, James Graba, Alison M.Y. Cheung, Bina S. Mystry, Jonathan R. Lindner, Robert S. Kerbel, and F. Stuart Foster Molecular Imaging. 2007 Sep-Oct; 6(5): PP. 289–296 View Journal Brief
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Combination Treatment with TRA-8 Anti Death Receptor 5 Antibody and CPT-11 Induces Tumor Regression in an Orthotopic Model of Pancreatic Cancer
Derosier LC, Buchsbaum DJ, Oliver PG, Huang ZQ, Sellers JC, Grizzle WE, Wang W, Zhou T, Zinn KR, Long JW, Vickers SM Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama Clin Cancer Res. 2007 Sep 15;13(18):5535s-43s View Journal Brief
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Biodegradable nanoparticles for targeted ultrasound imaging of breast cancer cells in vitro
Jun Liu, Jie Li, Thomas J Rosol, Xueliang Pan and Jeffrey L Voorhees Department of Biomedical Engineering, Ohio State University PHYSICS IN MEDICINE AND BIOLOGY,2007 Aug 21;52(16):4739-47. Epub 2007 Jul 24 View Journal Brief
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Detecting Vascular Changes In Tumour Xenografts Using Micro-Ultrasound And Micro-Ct Following Treatment With VEGFR-2 Blocking Antibodies
ALISON M. Y. CHEUNG,* ALLISON S. BROWN,* VIVIENE CUCEVIC,* MARCIA ROY,* ANDREW NEEDLES,* VICTOR YANG,* DANIEL J. HICKLIN,‡ ROBERT S. KERBEL,† and F. STUART FOSTER* *Imaging Research and †Molecular and Cell Biology, Sunnybrook and Women’s College Health Sciences Centre, Toronto, ON, Canada; and ‡ImClone Systems, New York, NY, USA Ultrasound in Med. & Biol. 2007 Aug;33(8):1259-68. Epub 2007 Apr 30 View Journal Brief
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Ultrasound biomicroscopy permits in vivo characterization of zebrafish liver tumors
Goessling W, North TE, Zon LI. Stem Cell Program, Hematology/Oncology, Children's Hospital and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts Nat Methods. 2007 Jul;4(7):551-3. Epub 2007 Jun 17 View Journal Brief
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Therapeutic effect of CS-706, a specific cyclooxygenase-2 inhibitor, on gallbladder carcinoma in BK5.ErbB-2 mice
Kiguchi K, Ruffino L, Kawamoto T, Franco E, Kurakata S, Fujiwara K, Hanai M, Rumi M, Digiovanni J. Department of Carcinogenesis, The University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville, TX Mol Cancer Ther. 2007 Jun;6(6):1709-17. View Journal Brief
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Vitamin E Analogs, a Novel Group of
Jiri Neuzil, Marco Tomasetti, Yan Zhao, Lan-Feng Dong, Marc Birringer, Xiu-Fang Wang, Pauline Low, Kun Wu, Brian A. Salvatore, and Steven J. Ralph Apoptosis Research Group, School of Medical Science, Griffith University, Southport, Queensland, Australia (J.N., L.F.D., X.F.W.); Molecular Therapy Group, Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic (J.N.); Department of Nutrition and Food, Harbin Medical University, Harbin, Heilongjiang Province, China (Y.Z., K.W.); Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy (M.T.); Institute of Human Nutrition, Friedrich Schiller University, Jena, Germany (M.B.); Genomic Research Centre, School of Medical Science, Griffith University, Southport, Queensland, Australia (P.L., S.J.R.); and Department of Chemistry and Physics, Louisiana State University, Shreveport, Louisiana (B.A.S.) Molecular Pharmacology. 2007 May;71(5):1185-99. Epub 2007 Jan 12 View Journal Brief
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Design, calibration and evaluation of a robotic needle-positioning system for small animal imaging applications
Waspe AC, Cakiroglu HJ, Lacefield JC, Fenster A. Biomedical Engineering Graduate Program, University of Western Ontario, London, Ontario Phys Med Biol. 2007 Apr 7;52(7):1863-78. Epub 2007 Mar 9. View Journal Brief
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A Peptide Conjugate of Vitamin E Succinate Targets Breast Cancer Cells with High ErbB2 Expression
Wang XF, Birringer M, Dong LF, Veprek P, Low P, Swettenham E, Stantic M, Yuan LH, Zobalova R, Wu K, Ledvina M, Ralph SJ, Neuzil J. Apoptosis Research Group and Genomics Research Centre, School of Medical Science, Griffith University, Southport, Queensland, Australia. Cancer Res. 2007 Apr 1;67(7):3337-44. View Journal Brief
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Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound
Jim W. Xuan,1, Michael Bygrave6, Hongyi Jiang1, Fatma Valiyeva1, Joy Dunmore-Buyze6, David W. Holdsworth2,6, Jonathan I. Izawa1, Glenn Bauman3, Madeleine Moussa4, Scott F. Winter7, Norman M. Greenberg7, Joseph L. Chin1, Maria Drangova2,6, Aaron Fenster2,3,6 and James C. Lacefield2,5,6 Departments of 1 Surgery, 2 Medical Biophysics, 3 Oncology, 4 Pathology, and 5 Electrical and Computer Engineering, University of Western Ontario and 6 Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada; and 7 Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington Cancer Research. 2007 Mar 15; 67, 2830-2839 View Journal Brief
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Ultrasonic characterization of whole cells and isolated nuclei
Taggart LR, Baddour RE, Giles A, Czarnota GJ, Kolios MC. Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, ON, Canada Ultrasound Med Biol. 2007 Mar;33(3):389-401 View Journal Brief
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Blockade of Hedgehog Signaling Inhibits Pancreatic Cancer Invasion and Metastases: A New Paradigm for Combination Therapy in Solid Cancers
Georg Feldmann1,5, Surajit Dhara1,5, Volker Fendrich2, Djahida Bedja3, Robert Beaty1,5, Michael Mullendore1,5, Collins Karikari1,5, Hector Alvarez1,5, Christine Iacobuzio-Donahue1,5, Antonio Jimeno4, Kathleen L. Gabrielson3, William Matsui4 and Anirban Maitra1,4,5 Departments of 1 Pathology, 2 Surgery, 3 Comparative Medicine, and 4 Oncology, 5 The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland Cancer Research. 2007 Mar 1;67(5):2187-96 View Journal Brief
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Secoisolariciresinol Diglucoside: Relevance to Angiogenesis and Cardioprotection against Ischemia-Reperfusion Injury
Suresh Varma Penumathsa, Srikanth Koneru, Mahesh Thirunavukkarasu, Lijun Zhan, Kailash Prasad, and Nilanjana Maulik Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health Center, Farmington, Connecticut (S.V.P., S.K., M.T., L.Z., N.M.); and Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada (K.P.) The Journal of Pharmacology and experimental therapeutics. 2007 Feb;320(2):951-9. Epub 2006 Nov 28 View Journal Brief
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Therapy-Induced Acute Recruitment of Circulating Endothelial Progenitor Cells to Tumors
Shaked Y, Ciarrocchi A, Franco M, Lee CR, Man S, Cheung AM, Hicklin DJ, Chaplin D, Foster FS, Benezra R, Kerbel RS. Department of Molecular and Cellular Biology Research, Sunnybrook Health Sciences Centre, Toronto Science. 2006 Sep 22;313(5794):1785-7 View Journal Brief
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The Use of Targeted Mouse Models for Preclinical Testing of Novel Cancer Therapeutics
Kenneth P. Olive and David A. Tuveson University of Vermont, Cardiovascular Research Institute Burlington, VT, USA. Clinical Cancer Research2006 Sept 15; Vol. 12, 5277-5287 View Journal Brief
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Rapamycin improves lymphoproliferative disease in murine autoimmune lymphoproliferative syndrome (ALPS)
David T. Teachey, Dana A. Obzut, Kelly Axsom, John K. Choi, Kelly C. Goldsmith, Junior Hall, Jessica Hulitt, Catherine S. Manno, John M. Maris, Nicholas Rhodin, Kathleen E. Sullivan, Valerie I. Brown, and Stephan A. Grupp From the Divisions of Oncology, Hematology, and Immunology in the Department of Pediatrics, and the Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine Blood. 2006 Sept 15; Vol.108; No.6; 1965-1971. Epub June 6, 2006 View Journal Brief
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Characterization of Digital Waveforms Using Thermodynamic Analogs: Detection of Contrast-Targeted Tissue In Vivo
Michael S. Hughes, Member, IEEE, Jon N. Marsh, Member, IEEE, Hyuing Zhang, Adam K. Woodson, John S. Allen, Elizabeth K. Lacy, Cordelia Carradine, Gregory M. Lanza, and Samuel A. Wickline Washington University School of Medicine MO IEEE transactions on ultrasonics, ferroelectrics, and frequency control. 2006 Sep;53(9):1609-16 View Journal Brief
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Oncolytic Viral Therapy By Bladder Instillation Using An E1a, E1b Double-Restricted Adenovirus In An Orthotopic Bladder Cancer Model
Hua Wang, Makoto Satoh, Hisashi Abe, Makoto Sunamura, Takuya Moriya, Shigeto Ishidoya, Seiichi Saito, Hirofumi Hamada, And Yoichi Arai From the Division of Urology and Division of Gastroenterological Surgery, Department of Surgery, Tohoku University Graduate School of Medicine; Department of Pathology, Tohoku University Hospital, Sendia, Japan; and Department of Molecular Medicine, Sapporo Medical University, Sapporo, Japan Urology, 2006 Sep;68(3):674-81. Epub 2006 Sep 18 View Journal Brief
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Volume measurement variability in three-dimensional high-frequency ultrasound images of murine liver metastases
Wirtzfeld LA, Graham KC, Groom AC, Macdonald IC, Chambers AF, Fenster A, Lacefield JC. Biomedical Engineering Graduate Program, University of Western Ontario, Imaging Research Laboratories, Robarts Research Institute, London, Ontario. Phys Med Biol. 2006 May 21;51(10):2367-81. Epub 2006 Apr 26. View Journal Brief
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Nanosecond pulsed electric fields cause melanomas to self-destruct
Richard Nuccitellia, bUwe Pliquetta, Xinhua Chena, Wentia Forda, R. James Swansona, Stephen J. Beebea, c, Juergen F. Kolba and Karl H. Schoenbacha aFrank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, bBioElectroMed Corp., Norfolk, VA cEastern Virginia Medical School, Norfolk, VA Received 11 February 2006. Available online 10 March 2006. Biochem Biophys Res Commun. 2006 May 5;343(2):351-60. Epub 2006 Mar 10 View Journal Brief
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Phospholipase C-{delta}1 Is a Critical Target for Tumor Necrosis Factor Receptor-Mediated Protection against Adriamycin-Induced Cardiac Injury
Lien YC, Noel T, Liu H, Stromberg AJ, Chen KC, St Clair DK. Graduate Center for Toxicology, Department of Statistics, University of Kentucky, Lexington, Kentucky 40536, USA. Cancer Res. 2006 Apr 15;66(8):4329-38. View Journal Brief
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Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia
Franco M, Man S, Chen L, Emmenegger U, Shaked Y, Cheung AM, Brown AS, Hicklin DJ, Foster FS, Kerbel RS. Molecular and Cellular Biology Research, Sunnybrook and Women's College Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5. Cancer Research. 2006 Apr 1;66(7):3639-48. View Journal Brief
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Validation of Ultrasonography to Evaluate Murine Orthotopic Oral Cavity Tumors
Pezold JC, Zinn K, Talbert MA, Desmond R, Rosenthal EL. Department of Surgery, Division of Otolaryngology - Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Ala., USA. ORL J Otorhinolaryngol Relat Spec.2006 Apr; 68(3):159-63. Epub 2006 Feb 6 View Journal Brief
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Fibroblast-derived MT1-MMP promotes tumor progression in vitro and in vivo
Wenyue Zhang, Lynn M Matrisian, Kenn Holmeck, Catherine C Vick and Eben L Rosenthal Department of Surgery, Division of Otolaryngology - Head and Neck Surgery, University of Alabama at Birmingham, Birmingham, Ala., USA. BMC Cancer2006 March 6; 6:52 View Journal Brief
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Establishment of a serum tumor marker for preclinical trials of mouse prostate cancer models
Huizen IV, Wu G, Moussa M, Chin JL, Fenster A, Lacefield JC, Sakai H, Greenberg NM, Xuan JW Departments of Surgery, Pathology and Imaging Research Laboratories, Robarts Research Institute, London, Ontario. Clin Cancer Res. 2005 Nov 1;11(21):7911-9 View Journal Brief
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The use of three-dimensional ultrasound micro-imaging to monitor prostate tumor development in a transgenic prostate cancer mouse model
Wu G, Wang L, Yu L, Wang H, Xuan JW. Department of Urology, Xi-jing Hospital, the Fourth Military Medical University, Xi'an. wuguojun@fmmu.edu.cn Tohoku J Exp Med. 2005 Nov;207(3):181-9. View Journal Brief
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Ultrasonic Molecular Imaging of Primordial Angiogenic Vessels in Rabbit and Mouse Models With v3-integrin Targeted Nanoparticles Using Information-Theoretic Signal Detection: Results at High Frequency and in the Clinical Diagnostic Frequency Range
M. Hughes, J. N. Marsh, Jeffrey Arbeit, Robert Neumann,R. W. Fuhrhop, G. M. Lanza, and S. A. Wickline Washington University School of Medicine IEEE Ultrasonics Symposium. 2005 Sept 18-21; Vol: 1, PP. 617- 620 View Journal Brief
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Chemopreventive and Therapeutic Efficacy of Orally Active Tyrosine Kinase Inhibitors in a Transgenic Mouse Model of Gallbladder Carcinoma
Kaoru Kiguchi1, Lynnsie Ruffino1, Toru Kawamoto1,2, Tetsuo Ajiki1 and John DiGiovanni1 1Department of Carcinogenesis, The University of Texas, M.D. Anderson Cancer Center, Science Park-Research Division, Smithville, Texas and 2 Department of Surgery, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan Clinical Cancer Research2005 Aug 1; Vol. 11, 5572-5580 View Journal Brief
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A new three-dimensional ultrasound microimaging technology for preclinical studies using a transgenic prostate cancer mouse model
Wirtzfeld LA, Wu G, Bygrave M, Yamasaki Y, Sakai H, Moussa M, Izawa JI, Downey DB, Greenberg NM, Fenster A, Xuan JW, Lacefield JC. Biomedical Engineering Graduate Program and Departments of Surgery, Pathology, Diagnostic Radiology and Nuclear Medicine, Medical Biophysics, and Electrical and Computer Engineering, University of Western Ontario. Cancer Res. 2005 Jul 15;65(14):6337-45. View Journal Brief
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Three-dimensional High-Frequency Ultrasound Imaging for Longitudinal Evaluation of Liver Metastases in Preclinical Models
Graham KC, Wirtzfeld LA, Mackenzie LT, Postenka CO, Groom AC, Macdonald IC, Fenster A, Lacefield JC, Chambers AF. Department of Medical Biophysics, The University of Western Ontario, London, Canada Cancer Research. 2005 Jun 15;65(12):5231-7. View Journal Brief
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Three-dimensional ultrasound biomicroscopy for xenograft growth analysis
Cheung AM, Brown AS, Hastie LA, Cucevic V, Roy M, Lacefield JC, Fenster A, Foster FS. Imaging Research, Sunnybrook and Women's College Health Sciences Center, Toronto, ONT, Canada. Ultrasound Med Biol. 2005 Jun;31(6):865-870. View Journal Brief
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High-frequency Doppler ultrasound monitors the effects of antivascular therapy on tumor blood flow.
Goertz DE, Yu JL, Kerbel RS, Burns PN, Foster FS. Sunnybrook and Women's College Health Sciences Centre, Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M4N 3M5 Canada Cancer Research. 2002 Nov 15;62(22):6371-5. View Journal Brief
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Ultrasound Imaging of Apoptosis: DNA-Damage Effects Visualized
Gregory J. Czarnota, Michael C. Kolios, John W. Hunt, Michael D. Sherar Department of Radiation Oncology, University of Toronto, Ryerson University, Toronto, Canada Methods in Molecular Biology. 2002 Apr 30; vol. 203, pp. 257-277. View Journal Brief
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Ultrasound backscatter microscope analysis of mouse melanoma progression
Turnbull DH, Ramsay JA, Shivji GS, Bloomfield TS, From L, Sauder DN, Foster FS. Skirball Institute of Biomolecular Medicine, New York University Medical Center, NY 10016, USA. Ultrasound Med Biol. 1996 Oct; 22(7):845-53. View Journal Brief
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