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Developmental Biology

Insight into early embryonic development

With the mouse being the preferred model for mammalian development and its applications for phenotypic analysis, the high-resolution Vevo imaging system makes it an invaluable tool for providing real-time visualization of anatomical structures and hemodynamic function in vivo in utero of small animals.

The Vevo system allows detailed in vivo visualization as early as embryonic day 5.5 through neonate to adulthood. The non-invasive nature of the system therefore facilitates longitudinal studies of the same mouse, providing added utility to phenotypic analysis. In addition to the mouse, the Vevo system is well-suited for other small animal models including the rat, chick embryo, and zebra fish. Furthermore 3D images and quantification can also be generated.

Ability to detect early pregnancy/implantation:  

It allows screening of early embryonic structures as well as characterization and visualization of specific gestational stages.  Furthermore, the Vevo system allows you to observe embryonic resorption and to count the number of embryos present.

Visualize and quantify rodent embryonic development:

The ability to generate real-time images from embryonic day 4.5 in vivo provides the developmental biologist with a powerful research tool for assessment and measurement of target anatomy or physiology through to adulthood.

Extensive Measurement and Annotation Functionality:

The Vevo software provides measurement and annotation functionality that allows the developmental biologist to conduct comprehensive analysis for monitoring and measuring the progression of disease and the efficacy of therapeutics. Examples of calculation packages include:quantification of ejection fraction, fractional shortening, cardiac output, blood flow measurements, crown rump length.  Furthermore all data can be exported in excel and images can be formatted in BMP, TIFF, AVI, GIF and DICOM.

Real-time visualization of image-guided needle injections and extractions:

Targeted needle injections of cells, genetic material, drugs and retroviruses can be visualized in real-time in embryos.

Easy to learn and obtain results:

The Vevo software is simple to use so that researchers can maximize their time performing post-imaging analysis. User friendly offline software is available to analyze all data.  In addition, several on-line tutorials and protocols are available to allow researchers to learn quickly, analyze their data and obtain results.

 

Mouse Embryo Profile E12 where nucleated embryo blood shows the difference between heart chambers, major arteries (bright echoes) and cerebral-spinal fluid (dark), ventricle (dark). Imaged using B-Mode on Vevo 2100 system.

 

E12 Mouse and maternal placental flow shown by Color Doppler Mode. The direction and pulsing pattern identifies the anatomy. Imaged using Color Doppler Mode on Vevo 2100 system.

Commonly used terminology:

embryo, fetus, teratogenesis, embryogenesis, implantation, amnion, amniotic cavity, coelemic cavity, ectoplacental cavity, resorption, placenta, placental, OBGYN, obstetrics.