Dr. Lindner specializes in non-invasive cardiac imaging and has a clinical interest in ischemic heart disease. His research focuses on the use of contrast enhanced ultrasound perfusion imaging to study microvascular function in health and disease states such as coronary artery disease, myocardial infarction, diabetes mellitus, and peripheral vascular disease. Dr. Lindner leads a laboratory group that studies molecular imaging of inflammation, ischemia, and angiogenesis with site targeted ultrasound contrast agents; drug and gene delivery with ultrasound; and microvascular physiology at the capillary level.

Dr. Lindner is currently a Professor of Medicine and the Associate Chief for Education (Cardiovascular Division) at the Oregon Health & Science University. Prior to joining the faculty at OHSU, Dr. Lindner was at the University of Virginia where he was Professor of Medicine, Associate Chief for Research, Cardiovascular Division. His accomplishments include more than 200 scientific papers, review articles and abstracts, 3 patents and he has received numerous awards. He currently serves on the Board of Directors for the American Society for Echocardiography and is an elected member of the American Society of Clinical Investigation.

Recent Publications:

• >  Kaufmann B, Lankford M, Behm CZ, French BA, Klibanov AL, Xu Y, Lindner JR. High-resolution myocardial perfusion imaging in mice with high-frequency echocardiographic detection of a depot contrast agent. J Am Soc Echocardiogr Nat Rev Drug Discov. 2007;20:136-143.
  
  
• >  Kaufmann B, Sanders JM, Davis C, Xie A, Aldred P, Sarembock IJ, Lindner JR. Molecular imaging of inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule-I. J Circulation 2007;116:276-284.
  
  
• >  Leong-Poi H, Kuliszewski MA, Lekas M, Klibanov AR, Stewart DJ, Lindner JR. Targeted delivery of VEGF₁₆₅ by ultrasonic destruction of carrier microbubbles improves perfusion to chronically ischemic skeletal muscle. Circ Res 2007;101:295-303.
  
  
• >  Kaufmann B, Lewis C, Xie A, Mirza-Mohd A, Lindner JR. Detection of recent myocardial ischemia by molecular imaging of P-selectin with targeted contrast echocardiography. Eur Heart J 2007;28:2011-2017.
  
  
• >  Pascotto M, Leong-Poi H, Lankford M, Charalampdis D, Sanders JM, Kerut EK, Kaul S, Lindner JR. Assessment of ischemia-induced microvascular remodeling using contrast-enhanced ultrasound vascular anatomic mapping. J Am Soc Echocardiogr 2007;20:1100-1108.
  
  
• >  Clerk LH, Vincent MA, Barrett EJ, Lankford MF, Lindner JR. Skeletal muscle microvascular responses to insulin are abnormal in late-stage diabetes and are restored by angiotensin converting enzyme inhibition. Am J Physiol Endocrinol Metab 2007;293:E1804-E1809.
  
  
• >  Rychack J, Graba J, White C, Cheung A, Mistry B, Lindner J. Kerber RS, Foster FS. Microultrasound molecular imaging of VEGFR-2 in a mouse model of tumor angiogenesis. J Mol Imaging2007;6:289-296.
  
  
• >  Behm CZ, Kaufmann BA, Lankford M, Sanders JM, Kaul S, Lindner JR. Molecular imaging of VCAM-1 and inflammatory cell recruitment during arteriogenesis and vasculogenesis. Circulation 2008;117:2902-2911.
  
  
• >  Lindner JR, Womack L, Barrett EJ, Feltman J, Price W, Harthun NL, Patrie JT. Assessment of peripheral vascular disease by lower extremity contrast ultrasound perfusion imaging. J Am Coll Cardiol Img 2008;1:343-350.