Dr. Homma is a graduate of the Bronx High School of Science and Dartmouth College. He went on to graduate from Albert Einstein College of Medicine. Subsequently, he trained at Massachusetts General Hospial in Boston and Columbia-Presbyterian Medical Center in NYC, specializing in cardiac imaging. He now serves as the Margaret Milliken Hatch Professor of Medicine, Associate Chief of Cardiology Division and the director of Cardiovascular Ultrasound Laboratories at Columbia-University Medical Center. He is an author of over 400 scientific publications and his laboratory has received over $10 million in research funding in the last 10 years from the National Insitutute of Health (NIH). He is the Vice-President of New York Echo. Society, and the President of Japanese Medical Society of America.

Selected Publications:

• >  Wiedermann J, Leavy J, Amols H, Homma S, Di Tullio M, Sherman D, Apfelbaum M, Schwartz A, Weinberger J. Intracoronary irradiation acutely impairs endothelial and smooth muscle function as assessed by intravascular ultrasound. Am J Phys 1994; 267:H125-H132.
  

• >  Knecht M, Burkoff D, Yi GH, Popilskis S, Homma S, Packer M, Wang J. Coronary endothelial dysfunction precedes heart failure and reduction of coronary reserve in awake dogs. J Mol Cell Cardiol 1997;29:219-27.
  
  
• >  Todaka K, Leibowitz D, Homma S, Fisher PE, Derosa C, Stennett R, Packer M. Burkoff D. Characterizing ventricular mechanics and energetics following repeated coronary microembolization. Am J Phys 1997;272(1Pt2):H86-94.
  
  
• >  Fard A, Wang CY, Takuma S, Skopicki HA, Pinsky DJ, Di Tullio MR, Homma S. Noninvasive assessment and necropsy validation of changes in left ventricular mass in ascending aortic banded mice using a 12MHz probe. J Am Soc Echo 2000;13:582-7.
  
  
• >  Wang CY, Aronson I, Takuma S, Homma S, Naka Y, Alshafie T, Brovkovych V, Malinski T, Oz MC, Pinsky DJ. cAMP-mediated reduction in cardiac preservation injury reduces allograft and isograft vasculopathy. Circ Res 2000;86:982-988.
  
  
• >  Suehiro K, Takuma S, Shimizu J, Hozumi T, Wang J, Di Tullio M, Burkhoff D, Homma S. Assessment of segmental wall motion abnormalities using contrast two dimensional echocardiography in awake mice. Am J Physiol 2001;280:H1729-H1735.
  
  
• >  Takuma S, Suehiro K, Cardinale C, Yano H, Shimizu J, Mullis-Jansson S, Sciacca R, Wang J, Burkhoff D, Di Tullio MR, Homma S. Anesthetic inhibition in ischemic and non-ischemic murine heart: comparison with conscious echocardiographic approach for functional assessment. Am J Physiol 2001;280:H2364-2370.
  
  
• >  Kocher AA, Schuster MD, Szabolcs MJ, Takuma S, Burkhoff D, Wang JF, Homma S, Edwards NM, Itescu S. Neoangiogenesis of ischemic myocardium by human adult bone marrow-derived angioblasts prevents post-infarction remodeling and improves cardiac function. Nature Medicine 2001;7:1-7.
  
  
• >  Takuma S, Cabreriza SE, Sciacca R, Di Tullio MR, Spotnitz HM, Homma S. Determination of left ventricular mass by real-time three-dimensional echocardiography: in vitro validation. Echocardiography 2000;17:665-74.
  
  
• >  Takuma S, Ota T, Muro T, Oropesa I, Sciacca R, Mendoza L, Di Tullio MR, Blood DK Yoshikawa J, Homma S. Assessment of left ventricular volumes by real-time 3D echocardiography compared with conventional noninvasive methods. J Am Soc Echo 2000;14:275-284.
  
  
• >  Suehiro K, Takuma S, Shimizu J, Hozumi T, Yano H, Cardinale C, Di Tullio M, Wang J, Burkhoff D, Homma S. Assessment of left ventricular systolic function using contrast two-dimensional echocardiography with a high-frequency transducer in awake murine model of myocaridal infarction. Jpn Circ Jl 2001;65:979-83.
  
  
• >  Lu L, Mei DF, Gu AG, Wang S, Lentzner B, Gutstein DE, Zwas D, Homma S, Yi GH. Wang J. Exercise training normalizes altered calcium handling proteins during development of heart failure. J Appl Phys 2002;92:1524-30.
  
  
• >  Wang CY, Mazer SP, Takuma S, Homma S, Yellin M, Chess L, Fard A, Kalled S, Oz M, Pinsky DJ. Suppression of murine cardiac allograft arteriopathy by chronic blockade of cd40-cd154 interactions. Circulation 2002;105:1609-14.
  
  
• >  Yagyu H, Chen C, Yokoyama M, Hirata K, Augustus A, Kako Y, Seo T, Hu Y, Lutz EP, Merkel M, Bensadoun A, Homma S, Goldberg IJ. Lipoprotein lipase (LpL) on the surface of cardiomyocytes increased lipid uptake and produces a cardiomyopathy. J Clin Invest 2003; 11:419-426.
  
  
• >  Sun L, Takuma S, Liu R, Homma S. Effect of maternal cocaine exposure on fetal rat cardiac function. Anesth Analg 2003; 97:878-82.
  
  
• >  Yokoyama M, Yagyu H, Hu Y, Seo T, Hirata K, Homma S, Goldberg IJ. Apolipoprotein B production reduces lipotoxic cardiomyopathy: Studies in heart specific lipoprotein lipase transgenic mouse. J Biol Chem 2004; 279:4204-11.
  
  
• >  Schuster MD, Kocher AA, Seki T, Matrens TP, Xiang G, Homma S, Itescu S. Myocardial neovascularization by bone marrow angioblasts results in cardiomyocyte regeneration. Am J Phsiol 2004;287:H525-32.
  
  
• >  Hwang YC, Kaneko M, Barr S, Kakr S, Liao H, Lu Y, Lewis ER, Yan SD, Ii S, Itakura M, Liu R, Skopicki H, Homma S, Schmidt AM, Oates PJ, Szabolcs M, Ramasamy R. Central role for aldose reductase pathway in myocardial ischemic injury. FASEB J 2004;18:1192-9.
  
  
• >  Vikramadithyan RK, Hirata K, Yagyu H, Hu Y, Augustus A, Homma S, Goldberg IJ. Peroxisome proliferator activated receptor agonists modulate heart function in transgenic mice with lipotoxic cardiomyopathy. J Pharmacol Exp Ther. 2005; (in press)