S. Lee Adamson, Ph.D. Director, CMHD Mouse Physiology Lab Senior Scientist, Samuel Lunenfeld Research Institute Professor, Obstetrics & Gynecology, University of Toronto Mount Sinai Hospital, Toronto, ON Dr. Adamson's laboratory uses the mouse as a model to explore the developmental mechanisms responsible for abnormal waveforms in the umbilical and uterine arteries, and the impact of abnormal flows on fetal growth and development. Maternal and fetal cardiovascular function are monitored using the Vevo 660 high frequency ultrasonic imaging system and Doppler blood velocities. Utero- and feto-placental structures are being assessed using histological and vascular casting techniques. Recent Publications >  Zhou YQ, Foster FS, Qu DW, Zhang M, Harasiewicz KA, Adamson SL. Applications for multifrequency ultrasound biomicroscopy in mice from implantation to adulthood. Physiol Genomics. 2002 Aug 14;10(2):113-26. >  Wong AY, Kulandavelu S, Whiteley KJ, Qu D, Langille BL, Adamson SL. Maternal cardiovascular changes during pregnancy and postpartum in mice. Am J Physiol Heart Circ Physiol. 2002 Mar;282(3):H918-25. >  Foster FS, Zhang MY, Zhou YQ, Liu G, Mehi J, Cherin E, Harasiewicz KA, Starkoski BG, Zan L, Knapik DA, Adamson SL. A new ultrasound instrument for in vivo microimaging of mice. Ultrasound Med Biol. 2002 Sep;28(9):1165-72. >  Adamson SL, Lu Y, Whiteley KJ, Holmyard D, Hemberger M, Pfarrer C, Cross JC. Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta. Dev Biol. 2002 Oct 15;250(2):358-73. >  Cross JC, Hemberger M, Lu Y, Nozaki T, Whiteley K, Masutani M, Adamson SL. Trophoblast functions, angiogenesis and remodeling of the maternal vasculature in the placenta. Mol Cell Endocrinol. 2002 Feb 22;187(1-2):207-12.